| Final A | Team | time | -)time | L | React. | 100m | 200m | 300m | | 1. Thiago Pereira | BRA | 4:16.68 | | 5 | 0.72s | 1. | 56.64s | 1. | 2:00.98 | 1. | 3:12.27 | | 2. Conor J Dwyer | USA | 4:18.22 | 1.54s | 4 | 0.69s | 2. | 58.36s | 2. | 2:03.74 | 2. | 3:18.51 | | 3. Robert John Margalis Jr | USA | 4:24.88 | 8.20s | 3 | 0.72s | 3. | 59.64s | 3. | 2:05.30 | 3. | 3:22.13 | | 4. Esteban Enderica | ECU | 4:26.43 | 9.75s | 6 | 0.68s | 4. | 1:00.26 | 5. | 2:08.36 | 4. | 3:24.44 | | 5. Ezequiel Trujillo | MEX | 4:30.02 | 13.34s | 2 | 0.79s | 5. | 1:00.84 | 4. | 2:08.35 | 5. | 3:25.01 | | 6. Lyam Dias | CAN | 4:34.11 | 17.43s | 8 | 0.64s | 6. | 1:01.42 | 7. | 2:14.60 | 7. | 3:30.42 | | 7. Diogo Yabe | BRA | 4:35.66 | 18.98s | 1 | 0.80s | 7. | 1:02.02 | 6. | 2:12.84 | 6. | 3:29.98 | | 8. Esteban Paz | ARG | 4:37.67 | 20.99s | 7 | 0.90s | 8. | 1:03.31 | 8. | 2:16.03 | 8. | 3:36.06 |
| Final B | Team | time | -)time | L | React. | 100m | 200m | 300m | | 9. Diego Castillo | PAN | 4:40.04 | | 5 | | 1. | 1:01.09 | 2. | 2:15.04 | 2. | 3:37.91 | | 10.Eddy Marin | VEN | 4:40.08 | 0.04s | 4 | 0.73s | 2. | 1:01.40 | 1. | 2:14.71 | 1. | 3:37.48 |
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| World record: | | Michael Phelps (USA) 4:03.84 | | Beijing (CHN) 10.08.2008 | | Pan American Games record: | | Thiago Pereira (BRA) 4:11.14 | | Rio de Janeiro (BRA) 17.07.2007 |
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| Qualification: | | Standard A: 4:34.2 | | Standard B: 4:41.5 |
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| Heats | Team | time | -)time | L | React. | 100m | 200m | 300m | Heat | | 1. Conor J Dwyer | USA | 4:24.98 | | 5 | 0.69s | 2. | 58.97s | 2. | 2:05.20 | 2. | 3:19.94 | Heat 2. | | 2. Thiago Pereira | BRA | 4:26.27 | 1.29s | 4 | 0.74s | 1. | 58.48s | 1. | 2:03.81 | 1. | 3:19.91 | Heat 2. | | 3. Robert John Margalis Jr | USA | 4:29.70 | 4.72s | 4 | 0.71s | 2. | 1:00.87 | 1. | 2:08.37 | 1. | 3:25.70 | Heat 1. | | 4. Esteban Enderica | ECU | 4:31.15 | 6.17s | 3 | 0.68s | 4. | 1:00.01 | 4. | 2:10.27 | 4. | 3:28.12 | Heat 2. | | 5. Ezequiel Trujillo | MEX | 4:31.31 | 6.33s | 6 | 0.73s | 5. | 1:00.48 | 3. | 2:09.43 | 3. | 3:26.95 | Heat 2. | | 6. Esteban Paz | ARG | 4:34.08 | 9.10s | 6 | 0.95s | 5. | 1:02.80 | 2. | 2:12.10 | 3. | 3:32.34 | Heat 1. | | 7. Diogo Yabe | BRA | 4:34.18 | 9.20s | 5 | 0.82s | 4. | 1:01.82 | 3. | 2:13.32 | 2. | 3:31.33 | Heat 1. | | 8. Lyam Dias | CAN | 4:37.60 | 12.62s | 3 | 0.68s | 3. | 1:01.76 | 5. | 2:16.11 | 4. | 3:33.65 | Heat 1. | | 9. Eddy Marin | VEN | 4:38.88 | 13.90s | 2 | 0.77s | 1. | 1:00.25 | 4. | 2:13.69 | 5. | 3:34.81 | Heat 1. | | 10.Diego Castillo | PAN | 4:45.31 | 20.33s | 2 | | 3. | 59.01s | 5. | 2:11.72 | 5. | 3:35.57 | Heat 2. | | 11.Joel Joseph Romeu | URU | 4:53.76 | 28.78s | 7 | 0.71s | 6. | 1:01.72 | 6. | 2:17.30 | 6. | 3:45.86 | Heat 2. |
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