| Final A | Team | time | -time | L | React. | 50m | | 1. Cesar Cielo | BRA | 47.84s | RP | 4 | 0.70s | 1. | 22.84s | | 2. Hanser Garcia | CUB | 48.34s | 0.50s | 3 | | 4. | 23.54s | | 3. Shaune Fraser | CAY | 48.63s | 0.79s | 5 | 0.71s | 3. | 23.21s | | 4. Douglas Robison | USA | 48.98s | 1.14s | 6 | 0.75s | 6. | 23.80s | | 5. Brett Fraser | CAY | 49.07s | 1.23s | 2 | 0.67s | 2. | 23.20s | | 6. Robert Savulich | USA | 49.62s | 1.78s | 7 | 0.69s | 5. | 23.60s | | 7. Cristian Quintero | VEN | 49.75s | 1.91s | 1 | 0.72s | 8. | 23.94s | | 8. Benjamin Hockin | PAR | 50.03s | 2.19s | 8 | 0.75s | 7. | 23.86s |
| Final B | Team | time | -time | L | React. | 50m | | 9. Federico Grabich | ARG | 49.95s | | 4 | 0.72s | 1. | 23.81s | | 10.José Gabriel Melconian | URU | 50.30s | 0.35s | 5 | 0.74s | 2. | 24.05s | | 11.Shawn Clarke | BAR | 51.00s | 1.05s | 6 | 0.74s | 3. | 24.43s | | 12.Rory Biskupski | CAN | 51.15s | 1.20s | 3 | | 4. | 24.87s | | 13.Alejandro Escudero | MEX | 51.66s | 1.71s | 2 | 0.72s | 5. | 24.89s | | 14.Mario Montoya | CRC | 51.83s | 1.88s | 7 | 0.75s | 8. | 25.19s | | 15.Raul Martinez | PUR | 51.94s | 1.99s | 1 | 0.74s | 7. | 25.18s | | 16.Antonio Cisneros | MEX | 52.55s | 2.60s | 8 | 0.73s | 6. | 25.04s |
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| World record: César Cielo Filho (BRA) 46.91s | | Roma (ITA) 30.07.2009 | | Pan American Games record: César Cielo Filho (BRA) 48.79s | | Rio de Janeiro (BRA) 18.07.2007 |
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| Qualification: | | Standard A: 50.4s | | Standard B: 51.9s |
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| Heats | Team | time | -time | L | React. | 50m | Heat | | 1. Cesar Cielo | BRA | 48.89s | | 4 | 0.70s | 1. | 22.94s | Heat 3. | | 2. Shaune Fraser | CAY | 49.00s | 0.11s | 3 | 0.72s | 2. | 23.46s | Heat 3. | | 3. Hanser Garcia | CUB | 49.08s | 0.19s | 5 | 0.86s | 3. | 23.65s | Heat 3. | | 4. Douglas Robison | USA | 49.09s | 0.20s | 5 | 0.74s | 1. | 23.95s | Heat 2. | | 5. Brett Fraser | CAY | 49.16s | 0.27s | 4 | 0.67s | 1. | 23.47s | Heat 1. | | 6. Robert Savulich | USA | 49.58s | 0.69s | 5 | 0.68s | 2. | 23.70s | Heat 1. | | 7. Cristian Quintero | VEN | 49.87s | 0.98s | 6 | 0.67s | 4. | 24.03s | Heat 1. | | 8. Benjamin Hockin | PAR | 49.91s | 1.02s | 3 | 0.76s | 2. | 24.03s | Heat 2. | | 9. Federico Grabich | ARG | 50.20s | 1.31s | 3 | 0.72s | 3. | 23.91s | Heat 1. | | 10.Crox Acuna | VEN | 50.35s | 1.46s | 6 | 0.72s | 4. | 24.25s | Heat 3. | | 11.Bruno Fratus | BRA | 50.51s | 1.62s | 4 | 0.77s | 3. | 24.40s | Heat 2. | | 12.José Gabriel Melconian | URU | 51.02s | 2.13s | 6 | 0.72s | 6. | 24.66s | Heat 2. | | 13.Rory Biskupski | CAN | 51.12s | 2.23s | 2 | 0.70s | 7. | 24.99s | Heat 3. | | 14.Shawn Clarke | BAR | 51.18s | 2.29s | 7 | 0.75s | 5. | 24.61s | Heat 3. | | 15.Alejandro Escudero | MEX | 51.38s | 2.49s | 1 | 0.74s | 5. | 24.65s | Heat 2. | | 16.Mario Montoya | CRC | 51.86s | 2.97s | 7 | 0.75s | 6. | 25.07s | Heat 1. | | 17.Raul Martinez | PUR | 52.06s | 3.17s | 7 | 0.70s | 4. | 24.59s | Heat 2. | | 18.Antonio Cisneros | MEX | 52.42s | 3.53s | 1 | 0.71s | 6. | 24.92s | Heat 3. | | 19.Branden Whitehurst | ISV | 52.45s | 3.56s | 2 | 0.77s | 7. | 25.05s | Heat 2. | | 20.Roy-Allan Burch | BER | 52.87s | 3.98s | 2 | 0.68s | 5. | 24.65s | Heat 1. | | 21.Perry Lindo | AHO | 53.32s | 4.43s | 8 | 0.80s | 8. | 25.01s | Heat 3. | | 22.Esau Walter Simpson | GRE | 54.73s | 5.84s | 1 | 0.73s | 7. | 25.60s | Heat 1. | | 23.Niall Roberts | GUY | 55.45s | 6.56s | 8 | 0.80s | 8. | 26.14s | Heat 1. | | 24.Orel Jeffrey | ANT | 1:03.84 | 14.95s | 8 | 0.98s | 8. | 29.89s | Heat 2. |
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