| Final | time | L | | 1. South Africa |  RSA | 3:31.56 | 4 | | Chad le Clos (m) 48.50s, Clayton Jimmie (m) 50.22s, Marlies Ross (w) 57.10s, Karin Prinsloo (m) 55.74s | | 2. Egypt |  EGY | 3:32.52 | 5 | | Rowan El Badry (w), Mohammed Khaled (m), Farida Osman (w), Mohamed Sammy (m). | | 3. Algeria |  ALG | 3:40.93 | 6 | | Nazim Belkhodja (m), Souad Nafissa Cherouati (w), Badis Djendouci (m), Majda Chebaraka. | | 4. Tunisia |  TUN | 3:41.18 | 3 | | 5. Zimbabwe |  KEN | 3:42.05 | 8 | | 6. Mauritius |  MRI | 3:42.89 | 2 | | 7. Kenya | KEN | 3:49.86 | 1 | | 8. Mozambique |  MOZ | 3:55.93 | 7 |
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| New Event First time held at All Africa Games Swimming. |
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